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目的观察奥曲肽治疗乙肝后肝硬化并食管胃底静脉曲张破裂出血的疗效。方法 78例食管胃底静脉曲张破裂出血的住院患者随机分为2组:奥曲肽组36例采用奥曲肽治疗,对照组42例采用垂体后叶素+硝酸甘油联合治疗。分别比较两组止血有效率、平均止血时间、7d内再出血率、并发症发生率及药物不良反应。结果奥曲肽组在显效率、总有效率、平均止血时间、7d内再出血率、并发症发生率方面均优于对照组,差异具有统计学意义(P<0.05或P<0.01);奥曲肽组不良反应发生率显著低于对照组(x2=5.7115,P<0.05),差异具有统计学意义。结论奥曲肽治疗食管胃底静脉曲张破裂出血的止血效果优于垂体后叶素,不良反应少,尤其对于中老年患者及原有心血管疾病患者耐受性好,可列为首选。
Objective To observe the curative effect of octreotide on hepatitis B cirrhosis and esophageal variceal bleeding. Methods A total of 78 inpatients with esophageal variceal bleeding were randomly divided into two groups: 36 patients in the octreotide group were treated with octreotide, and 42 patients in the control group were treated with pituitrin combined with nitroglycerin. The effective rate of hemostasis, the average hemostasis time, the rate of rebleeding within 7 days, the complication rate and adverse drug reactions were compared between the two groups. Results The octreotide group was better than the control group in apparent efficiency, total effective rate, mean hemostasis time, rebleeding rate within 7 days and complication rate (P <0.05 or P <0.01) The incidence of the reaction was significantly lower than that of the control group (x2 = 5.7115, P <0.05). The difference was statistically significant. Conclusion Octreotide is superior to pituitrin in the treatment of esophageal and gastric variceal bleeding and has fewer side effects. It is especially preferred for patients with middle-aged and elderly patients and patients with original cardiovascular disease.