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目的观察视网膜静脉阻塞患者的血脂改变,探讨高脂血症与视网膜静脉阻塞发病的关系。方法采用病例对照研究,病例组为确诊视网膜静脉阻塞且未接受过药物治疗的46例患者,对照组为年龄、性别与病例组无差异的45例健康查体者,既往无眼底血管性疾病史。检测血中总胆固醇、甘油三酯、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平,两组进行统计学比较。结果视网膜静脉阻塞病例组的总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均较对照组显著升高(P<0.05),而高密度脂蛋白胆固醇水平则显著低于对照组(P<0.05);病例组中视网膜中央静脉阻塞与视网膜分支静脉阻塞患者的上述四项指标比较差异无统计学意义(P>0.05)。结论高脂血症与视网膜静脉阻塞的发病密切相关。
Objective To observe the changes of blood lipids in patients with retinal vein occlusion and to explore the relationship between hyperlipidemia and the incidence of retinal vein occlusion. Methods A case-control study was conducted in 46 patients with confirmed retinal vein occlusion and no drug treatment. The control group consisted of 45 healthy subjects without any difference in age, sex and case group. There was no previous history of vascular disease . Blood total cholesterol, triglyceride, low density lipoprotein cholesterol and high density lipoprotein cholesterol levels were measured, and the two groups were compared statistically. Results The levels of total cholesterol, triglyceride and low density lipoprotein cholesterol in patients with retinal vein occlusion were significantly higher than those in control group (P <0.05), while the levels of high density lipoprotein cholesterol were significantly lower than those in control group (P <0.05 ). There was no significant difference in the above four indexes between the central retinal vein occlusion and the retinal branch vein occlusion in the case group (P> 0.05). Conclusion Hyperlipidemia is closely related to the incidence of retinal vein occlusion.