论文部分内容阅读
目的 :短期 1个月观察血管紧张素Ⅱ受体 (AT1型 )拮抗剂氯沙坦对临床糖尿病肾病 (DN)的作用。方法 :15例临床DN患者给予氯沙坦 5 0～ 10 0mg/d ,观察指标包括血压、尿蛋白 (总蛋白、IgG、白蛋白、转铁蛋白和视黄醇结合蛋白 )排泄、肾功能和血钾。结果 :与基础值相比 ,血压和 2 4h尿蛋白 (包括总蛋白、大分子、中分子和小分子蛋白 )明显降低 (P <0 .0 5 ) ;肾功能保持稳定 ,血钾轻度升高 ,但无统计学差异。结论 :氯沙坦在有效降低血压的同时 ,可能对DN提供较好的保护作用 ,不良反应少。
AIM: To observe the effect of losartan, an angiotensin Ⅱ receptor (AT1) antagonist, on clinical diabetic nephropathy (DN) in a short period of 1 month. Methods: Fifteen patients with clinical DN were given losartan 50 ~ 100 mg / d. The indexes of observation included excretion of blood pressure, urinary protein (total protein, IgG, albumin, transferrin and retinol binding protein), renal function and Potassium. Results: Compared with baseline, blood pressure and 24 h proteinuria (including total protein, macromolecule, middle and small molecule protein) were significantly decreased (P <0.05); renal function remained stable and serum potassium was slightly elevated High, but no statistical difference. Conclusion: Losartan can effectively reduce blood pressure, while DN may provide better protection, with fewer adverse reactions.