碘葡酰胺是一种非离子型水溶性含碘造影剂,自1973年问世以来,已应用于脊髓造影,脑池造影和脑室造影等,目前认为是一种较好的神经系统造影对比剂。我们自1989年采用此药用于脑立体定向术治疗岶金森氏病过程中,在7例碘葡酰胺脑室造影时,4例出现高热反应,症状严重,危及病人生命,故总结报告如下: 例1,男,35岁,因四肢震颤、僵硬6年余入院。既往无药物过敏史。入院8天在局麻下行右侧丘脑腹外侧核电凝术,穿刺右侧侧脑室前角成功后,缓慢气液交换,注入过滤空气30ml,继之注入经脑脊液稀释的碘葡酰胺(Amipaque)3ml,患者无恶心、呕吐、头痛等反应,手术顺利。注入药物2小时后出现剧烈寒战,体温开始升高,肌注安痛定4ml。半小时后病人意 Iodoglutamide is a non-ionic water-soluble iodine contrast agent, since its inception in 1973, has been used in myelography, cerebral cisterns and ventriculography, is now considered to be a good contrast contrast agent for the nervous system. We used this medicine since 1989 for the treatment of Parkinson’s disease with brain stereotactic process. In 7 cases of iodoglutamide intraventricular angiography, 4 cases showed hyperthermia reaction, the symptoms were serious, endangering the life of the patient, so the summary report is as follows: Example 1, male, 35 years old, due to limb tremor, stiffness more than 6 years admitted to hospital. Past history of drug allergy. Eight days after admission, the right ventromedial thalamic nucleocapsulotomy was performed under local anesthesia. After successful puncturing of the right lateral ventricle, slow gas-liquid exchange was performed and 30 ml of filtered air was injected followed by 3 ml of amipaque diluted with cerebrospinal fluid , Patients with nausea, vomiting, headache and other reactions, the operation goes well. 2 hours after the injection of drugs appeared severe chills, body temperature began to increase, intramuscular injection of Amway 4ml. Half an hour after the patient’s meaning