目的比较抗心磷脂抗体(ACA)和抗心肌线粒体抗体(ACMA)对扩张型心肌病(DCM)诊断及治疗评估价值。方法采用ELISA法测定DCM,30例患儿ACA-lgG和ACMA-lgG,并与健康者对照,同时检测心肌酶、心电图和多普勒超声心动图。结果DCM患儿ACA-lgG和ACMA-lgG阳性率分别为53.3%和40.0%,均显著高于健康者(P<0.01)。ACA-G阳性患儿心肌酶CK-MB、心律失常发生率、心腔扩大率、左心收缩功能降低率均显著高于ACA-lgG阴性者(P<0.05);而ACMA-lgG阳性与否同上述改变无明显相关性(P>0.05)。结论ACA-lgG阳性对DCM患者诊断和病情轻重判定均有重要意义;ACMA-lgG阳性虽对DCM患儿诊断有一定价值,但对病情判断无作用。 Objective To compare the diagnostic value of anticardiolipin antibodies (ACA) and anti-myocardial mitochondrial antibodies (ACMA) in the diagnosis and treatment of dilated cardiomyopathy (DCM). Methods The serum levels of ACA-lgG and ACMA-lgG in 30 children with DCM were measured by ELISA. The levels of myocardial enzymes, ECG and Doppler echocardiography were measured. Results The positive rates of ACA-lgG and ACMA-lgG in DCM children were 53.3% and 40.0% respectively, which were significantly higher than those in healthy children (P <0.01). The CK-MB, arrhythmia incidence, heart rate and left ventricular systolic function in ACA-G positive children were significantly lower than those in ACA-lgG negative children (P <0.05). However, ACMA-lgG positive or not No significant correlation with the above changes (P> 0.05). Conclusion ACA-lgG positivity is of great significance in the diagnosis of DCM patients and determination of severity. ACMA-lgG positivity has some value in the diagnosis of DCM, but has no effect on disease judgment.