曾有报告氨苯砜作为治疗药和用于疟疾预防可引起粒细胞缺乏症,死亡率可达40%,而乙胺嘧啶则无此现象。本文报告7例粒细胞缺乏症患者,开始每周口服Maloprim(氨苯砜100mg和乙胺嘧啶12.5mg)2片预防疟疾,7～9周后出现症状。其中男性3例,女性4例,年龄27～74岁。有2例是姐弟。6例在3年前均有过短暂脑缺血发作,而曾每日口服水杨酸。血液学检查5例白细胞数为0.1～0.7×10~9/l,多形核细胞为0～2%, Dapsone has been reported as a therapeutic drug and malaria prevention can cause agranulocytosis, the mortality rate up to 40%, while pyrimethamine did not. This article reports 7 patients with agranulocytosis, beginning weekly oral administration of 2 tablets of Maloprim (dapsone 100mg and pyrimethamine 12.5mg) to prevent malaria, 7 to 9 weeks after the onset of symptoms. There were 3 males and 4 females, ranging in age from 27 to 74 years. 2 cases are siblings. Six patients had a transient ischemic attack three years earlier, whereas oral salicylate was administered daily. Hematology 5 cases of white blood cell count was 0.1 ~ 0.7 × 10 ~ 9 / l, polymorphonuclear cells was 0 to 2%