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目的了解糖代谢异常与脉搏波速的关系,以尽早发现动脉粥样硬化。方法选择151例受试者进行标准75克口服糖耐量试验(75gOGTT),按OGTT结果分为糖耐量正常(NGT),糖耐量低减(IGT)及新诊断糖尿病(DM)三组。同时测定肱踝脉搏传导速度(BaPWV),并以肱踝脉搏传导速度(BaPWV)≥1400cm/s为诊断标准,将受试者分为动脉粥样硬化组和非动脉粥样硬化组。比较三组间动脉硬化的发生率。结果糖尿病组及糖耐量低减组动脉硬化的发生率显著增高(P<0.05)。结论脉搏波速在糖代谢异常(包括新诊断的2型糖尿病及糖耐量低减)人群显著增高,表明动脉粥样硬化在糖耐量低减阶段已经发生。
Objective To understand the relationship between abnormal glucose metabolism and pulse wave velocity in order to detect atherosclerosis as soon as possible. Methods Fifty-one subjects were enrolled in the standard 75 g oral glucose tolerance test (75 g OGTT). According to OGTT results, they were divided into three groups: normal glucose tolerance (IGT), impaired glucose tolerance (IGT) and newly diagnosed diabetes mellitus (DM). The brachial and ankle pulse conduction velocity (BaPWV) was measured at the same time. The patients were divided into atherosclerosis group and non-atherosclerosis group according to BaPWV≥1400cm / s. The incidence of atherosclerosis between the three groups was compared. Results The incidence of atherosclerosis was significantly higher in diabetic group and impaired glucose tolerance group (P <0.05). Conclusions Pulse wave velocity is significantly higher in people with abnormal glucose metabolism, including newly diagnosed type 2 diabetes and impaired glucose tolerance, suggesting that atherosclerosis has occurred in the stage of impaired glucose tolerance.