系统性红斑狼疮(SLE)的发病机制目前仍不十分清楚,但可以明确的是T细胞和B细胞与其发病相关[1,2]。在SLE中存在B细胞过度活化,产生大量自身反应性抗体,与相应自身抗原结合形成免疫复合物,沉积在各个组织、器官,并激活补体系统,引发一系列炎症反应,最终导致广泛的组织、器官损伤。B细胞在SLE发生、发展中发挥重要作用。因为B细胞可以产生抗体而被认为在自身免疫性疾病发生、 The pathogenesis of systemic lupus erythematosus (SLE) is still not very clear, but it is clear that T cells and B cells associated with its pathogenesis [1,2]. In SLE, B cells are over-activated, producing a large number of auto-reactive antibodies, binding to the corresponding autoantigens to form immune complexes, depositing in various tissues and organs, and activating the complement system, triggering a series of inflammatory responses that eventually lead to extensive tissue, Organ damage. B cells play an important role in the occurrence and development of SLE. Because B cells can produce antibodies and are thought to occur in autoimmune diseases,