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目的:通过对多囊卵巢综合征(PCOS)患者心脏指数的观察,探讨PCOS患者心脏功能的变化。方法:采用病例对照研究的方法,选取144例单纯PCOS患者为实验组,另选择129例月经周期正常、因输卵管因素或男方因素就诊的生育期不孕健康妇女作为对照组。两组患者均空腹12 h后于清晨抽取静脉血,采用全自动生化仪测定血脂水平,采用放射免疫法检测血清胰岛素水平,并由专业的超声医师记录心脏功能指数。结果:实验组患者体重指数(BMI)、腰臀比(WHR)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(Apo B)水平及胰岛素抵抗指数(HOMA-IR)高于对照组,差异均有统计学意义(P<0.05);两组高密度脂蛋白胆固醇(HDL-C)和载脂蛋白A1(Apo A1)水平相比较,差异无统计学意义(P>0.05)。实验组心脏指数二尖瓣口舒张早期的E峰峰值速度(PEV)、二尖瓣舒张早期最大血流速度(E)与舒张晚期最大血流速度(A)的比值(E/A)低于对照组,等容舒张期(IVRT)高于对照组,差异均有统计学意义(P<0.05);两组其余心脏指数比较,差异均无统计学意义(P>0.05)。结论:PCOS患者心脏舒张期功能是降低的。
Objective: To investigate the changes of cardiac function in PCOS patients by observing the cardiac index of patients with polycystic ovary syndrome (PCOS). Methods: One hundred and forty-four patients with simple PCOS were selected as experimental group and another 129 healthy women with normal menstrual cycle and infertility due to tubal factor or male factor were selected as control group. The venous blood was drawn in the early morning after fasting for 12 hours in both groups. The blood lipid level was measured by automatic biochemical analyzer. The level of serum insulin was measured by radioimmunoassay. The cardiac function index was recorded by a professional ultrasound physician. Results: The body mass index (BMI), WHR, TC, TG, LDL-C, Apo B And insulin resistance index (HOMA-IR) of the two groups were significantly higher than those of the control group (P <0.05). The levels of HDL-C and Apo A1 in the two groups were significantly higher than those in the control group , The difference was not statistically significant (P> 0.05). In the experimental group, the peak exponent (PEV) of mitral early diastole and the ratio of early mitral diastolic early blood flow (E) to late diastolic maximum blood flow (A) (E / A) In the control group, the IVRT was significantly higher than that in the control group (P <0.05). There was no significant difference in the remaining cardiac index between the two groups (P> 0.05). Conclusions: The diastolic function of PCOS patients is reduced.