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目的通过对难治性癫患儿进行生酮饮食,检测生酮饮食前后免疫功能各项指标的变化,分析生酮饮食对小儿难治性癫免疫功能的影响。方法选取该院36例癫患儿为观察组,给予生酮饮食;选取36例健康儿童为对照组;观察组生酮饮食前、饮食后1个月、3个月、6个月、12个月各采血1次;对照组儿童仅采血1次。采集空腹静脉血,测血清IgA、IgG、IgM及CD3、CD4、CD8。结果生酮饮食前,相对于正常儿童,难治性癫患儿IgA、IgG、CD8含量升高,CD3、CD4下降,差异有统计学意义(P<0.05)。相对于生酮饮食前,生酮饮食后3个月患儿IgA、IgG、CD8含量显著下降,CD3、CD4显著升高,差异有统计学意义(P<0.05),与正常儿童比较差异无统计学意义(P>0.05)。结论难治性癫患儿存在细胞免疫、体液免疫功能的紊乱,生酮饮食治疗后3个月免疫功能得到明显改善,癫发作得到有效控制,可能是生酮饮食治疗难治性癫的机制之一。
Objective To investigate the effects of ketogenic diet on the immune function of refractory epilepsy in children with refractory epilepsy by detecting ketogenic diet and detecting the changes of immune function before and after ketogenic diet. Methods Thirty-six children with epilepsy were enrolled in this study. The ketogenic diet was given. 36 healthy children were selected as the control group. Before the ketogenic diet, the mice in the observation group were treated with 1, 3, 6, 12 Blood samples were collected every month for one month; children in the control group only received blood once. Fasting venous blood was collected for serum IgA, IgG, IgM and CD3, CD4, CD8. Results Before ketogenic diet, the levels of IgA, IgG, CD8 and CD3 and CD4 in children with refractory epilepsy were significantly higher than those in normal children (P <0.05). Compared with the ketogenic diet, the content of IgA, IgG and CD8 in children after 3 months of ketogenic diet decreased significantly, and the levels of CD3 and CD4 were significantly increased (P <0.05), but there was no statistical difference compared with normal children Significance (P> 0.05). Conclusions Children with refractory epilepsy have disorder of cellular immunity and humoral immune function. Immune function is obviously improved in 3 months after ketogenic diet treatment, and epileptic seizures are effectively controlled. It may be that ketogenic diet is used to treat refractory epilepsy One of the mechanisms.