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目的 探讨妊娠时间作为妊娠早期生殖损伤观察指标的可行性。方法 以二硫化碳 (CS2 )作业女工为观察对象 ,①采用回顾性流行病学研究方法调查已孕女工妊娠所需的月经周期数 ;②应用前瞻性流行病学研究方法 ,追踪观察待孕女工至临床妊娠时的月经周期数 ;③整理回顾性研究现场空气中CS2 监测结果 ,监测前瞻性研究期间各观察对象接触CS2 浓度。结果 回顾性研究 (12 7名接触者和 10 8名对照 )和前瞻性流行病学研究 (2 5 7名接触者和 36 6名对照 )结果均表明 ,女工接触CS2 后各月经周期妊娠率明显低于对照组 ;且妊娠时间随其接触CS2 浓度的增高 (r =0 1198,P =0 0 2 4)及接触时间的增加 (r =0 2 799,P =0 0 0 0 )而延长。结论 妊娠时间可作为妊娠早期生殖损伤筛选指标之一。
Objective To explore the feasibility of gestational time as an indicator of reproductive injury during early pregnancy. Methods CS2 female workers were used as the observation objects. ①Retrospective epidemiological study was used to investigate the number of menstrual cycles required for pregnancies among pregnant women. (2) The prospective epidemiological study was used to observe the changes of pregnant women workers The number of menstrual cycles during pregnancy; ③ finishing a retrospective study of CS2 monitoring results of air in the field, monitoring the observation period during the prospective study of exposure to CS2 concentration. Results The results of retrospective studies (12 7 contacts and 10 8 controls) and prospective epidemiological studies (257 contacts and 366 controls) showed that pregnancy rates of women in each menstrual cycle were significantly higher after CS2 exposure (R = 0 1198, P = 0 024) and prolongation of contact time (r = 0 2799, P = 0 0 0 0). Conclusion Pregnancy time can be used as a screening index of reproductive injury in early pregnancy.