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目的探讨四联疗法治疗幽门螺杆菌阳性胃溃疡患者的临床效果。方法选取2015年6月至2016年6月锦州市中心医院收治的120例幽门螺杆菌阳性胃溃疡患作为研究对象,按照随机数字表法将其分为研究组(四联疗法)与对照组(三联疗法),各60例。比较两组患者溃疡愈合效果、幽门螺杆菌根除率、临床症状变化情况及不良反应发生情况。结果研究组、对照组患者溃疡愈合总有效率分别为100.0%(60/60)、90.0%(54/60),差异有统计学意义(P<0.05);研究组、对照组患者幽门螺杆菌根除率分别为91.7%(55/60)、90.0%(54/60),差异有统计学意义(P<0.05);研究组、对照组患者不良反应发生率分别为5.0%(3/60)、8.3%(5/60),差异无统计学意义(P>0.05);治疗后,研究组患者腹痛腹胀、反酸及嗳气评分均明显低于对照组,差异均有统计学意义(均P<0.05)。结论在幽门螺杆菌阳性胃溃疡患者的临床治疗过程中,采用四联疗法治疗效果显著。
Objective To investigate the clinical effect of quadruple therapy on patients with Helicobacter pylori-positive gastric ulcer. Methods A total of 120 cases of Helicobacter pylori-positive gastric ulcer patients admitted to Jinzhou Central Hospital from June 2015 to June 2016 were selected as the research objects. According to the random number table, they were divided into the study group (quadruple therapy group) and the control group Triple therapy), each 60 cases. The ulcer healing effect, Helicobacter pylori eradication rate, changes of clinical symptoms and incidence of adverse reactions were compared between the two groups. Results The total effective rates of ulcer healing in study group and control group were 100.0% (60/60) and 90.0% (54/60), respectively, with significant difference (P <0.05). In the study group and the control group, H. pylori The eradication rates were 91.7% (55/60) and 90.0% (54/60), respectively, with significant difference (P <0.05). The incidence of adverse reactions in study group and control group were 5.0% (3/60) , 8.3% (5/60) respectively. There was no significant difference between the two groups (P> 0.05). After treatment, abdominal pain, abdominal pain, acid reflux and belching score of study group were significantly lower than those of control group <0.05). Conclusion In the course of clinical treatment of patients with Helicobacter pylori-positive gastric ulcer, the effect of quadruple therapy is remarkable.