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阴道避孕药(又称外用避孕药)的含义是经阴道给药以实现控制生育的目的。应用时有单独应用和同其它避孕工具,如避孕套,避孕隔膜并用两种。它的主要优点是安全,全身性副反应小,应用方便和有可能预防某些性病等。因此,在发展和发达国家中已逐年增加了它的应用数量。但国内外目前市售的外用避孕产品中主要的有效成份,大都为一些表面活性型杀精子剂(如NP-9,“741”等)。为了尽快改变这一局面,研究者们正在积极地开发新型阴道避孕药。本文将近期有希望转化应用的一些新型杀精子剂及杀精子剂的药理学研究方法作一简单介绍,供有关研究者参考。一、新型阴道杀精子药的研究进展
Vaginal contraceptives (also known as topical contraceptives) means the vaginal delivery in order to achieve the purpose of birth control. There are separate applications for use with other contraceptives such as condoms and contraceptive diaphragms. Its main advantages are safety, systemic side effects, ease of use and the potential to prevent certain sexually transmitted diseases. As a result, its number of applications has been increasing year by year in both developed and developed countries. However, the main active ingredients of topical contraceptive products currently marketed at home and abroad are mostly surface-active spermicides (such as NP-9, “741”, etc.). In order to change this situation as soon as possible, researchers are actively developing new vaginal birth control pills. In this paper, some new methods of pharmacological research on some new type of spermicide and spermicide that are expected to be applied in transformation will be briefly introduced for reference of relevant researchers. A new vaginal spermicidal drug research progress