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目的:探讨男性阻塞性睡眠呼吸暂停(OSA)患者性功能改变的研究方法及影响因素。方法:对81例男性OSA患者,年龄(40.5±8.6)岁与35例健康志愿者,年龄(38.8±10)岁,采用亚利桑那性体验量表(ASEX)与Epworth嗜睡量表(ESS)问卷调查。以ASEX性驱动力项目评分4分归为性驱动力下降组[n=32,年龄(41.97±8.88)岁],评分<4归为非性驱动力下降组[n=49,年龄(39.49±8.29)岁],比较患者一般特征与PSG数据。将性驱动力评分与PSG数据做多元线性回归,评价影响性冲动能力因素。结果:OSA组患者ESS评分[(8±5)vs(5±4),P<0.05)]、ASEX评分[(10±2)vs(15±4),P<0.05)]均显著高于对照组;OSA患者中性驱动力下降组ESS评分[(9±5)vs(6±5),P<0.05)]、血氧饱和度低于90%时间(SIT90)[(41.01±26.95)vs(21.87±19.03),P<0.05)]显著高于非性驱动力下降组。多元回归分析显示年龄(β=0.25,P<0.001)、SIT90(β=0.4,P<0.001)影响OSA患者性冲动力评分。结论:OSA影响男性性功能的各个方面,其中以性驱动力下降最突出;夜间缺氧时间及年龄是OSA患者性驱动力下降的独立危险因素;性驱动力下降可视为OSA的一种主要临床症状。
Objective: To investigate the research methods and influential factors of sexual function changes in male patients with obstructive sleep apnea (OSA). Methods: A total of 81 male OSA patients aged 40.5 ± 8.6 years and 35 healthy volunteers aged 38.8 ± 10 years were enrolled in this study. The ASX and EpS Scale (ESS) questionnaire . A score of 4 was categorized as a non-sexual drive decline group [n = 49, age (39.49 ± 8.29) years old, comparing the general characteristics of patients with PSG data. Multiple linear regression was made between PSV and PSG data to evaluate the influencing factors of impulsivity. Results: The ESS score in OSA group was significantly higher than that in ESS group [(8 ± 5) vs (5 ± 4), P <0.05], ASEX score [(10 ± 2) vs (15 ± 4), P < (9 ± 5 vs 6 ± 5, P <0.05), and SIT90 [(41.01 ± 26.95) ng / vs (21.87 ± 19.03, P <0.05)] was significantly higher than that of non-sexual driving force. Multivariate regression analysis showed that age (β = 0.25, P <0.001) and SIT90 (β = 0.4, P <0.001) affected the impulsivity score of OSA patients. CONCLUSIONS: OSA affects all aspects of male sexual function, with the most prominent decline in sexual drive; nocturnal hypoxia time and age are independent risk factors for sexual drive decline in OSA patients; decreased sexual drive can be considered as a major OSA Clinical symptoms.