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目的 :对25例扁桃体原发性恶性肿瘤的临床病理特征 ,进行分析研究。方法 :收集25例经临床病理证实的扁桃体原发性恶性肿瘤患者的临床资料 ,复习有关病理组织常规切片 ,部分病例标本进行免疫组织化学染色、显微镜观察分析。结果 :鳞状细胞癌7例 ,恶性弥漫性非霍奇金淋巴瘤17例 ,血管肉瘤1例 ;淋巴瘤白细胞共同抗原(CD45)均为阳性表达 ,大多为B细胞来源 ,而细胞角蛋白(CK)均为阴性 ;鳞癌CK均为阳性表达 ,而CD45和波形蛋白(Vimentin)均为阴性 ;血管肉瘤表达F8和Vimentin。结论 :扁桃体原发性恶性肿瘤以弥漫性非霍奇金淋巴瘤最为常见 ,其次是鳞癌 ,最后确诊要依靠病理形态学及免疫组织化学来证实 ,并采取综合治疗
Objective: To analyze the clinical and pathological features of 25 cases of primary tonsillial malignancies. Methods: The clinical data of 25 patients with pathologically confirmed tonsil primary malignancies were collected. The histopathological sections were reviewed and immunohistochemical staining and microscopic observation were performed on some cases. Results: There were 7 cases of squamous cell carcinoma, 17 cases of malignant diffuse non-Hodgkin’s lymphoma and 1 case of angiosarcoma. The lymphoma leukocyte common antigen (CD45) were all positive, most of which were from B cells. The cytokeratin CK) were negative; squamous cell carcinoma were positive for CK, while both CD45 and vimentin were negative; angio-sarcoma expressed F8 and Vimentin. Conclusion: The primary tonsil malignancy is diffuse non-Hodgkin’s lymphoma is the most common, followed by squamous cell carcinoma, the final diagnosis depends on pathological morphology and immunohistochemistry to confirm and take a comprehensive treatment