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目的观察协同护理模式对溃疡性结肠炎患者IL-23、IL-17炎症因子及心理和躯体状况的影响。方法选择2013年1月—2014年12月浙江医院溃疡性结肠炎患者88例分为观察组和对照组。2组患者根据病情不同给予治疗,对照组给予常规护理,观察组在常规护理的基础上给予协同护理模式,观察2组患者治疗前后外周血中IL-17、IL-23的表达,对2组患者进行健康调查简易量表(SF-36)、抑郁自评调查。结果与治疗前比较,观察组和对照组治疗后IL-17、IL-23较治疗前均明显下降(P<0.05);观察组治疗后上述指标下降程度高于对照组(P<0.05);与治疗前比较,观察组和对照组干预后生活质量总分、精神健康、社会功能、情感职能、精力、躯体疼痛、健康状况、生理职能和心理功能评分均升高(P<0.05);且观察组干预后均高于对照组干预后(P<0.05),治疗前2组生活质量评分比较差异无统计学意义(P>0.05)。与治疗前比较,观察组和对照组干预后抑郁自评评分均降低(P<0.05);观察组治疗后抑郁自评评分低于对照组(P<0.05),治疗前2组抑郁自评评分比较差异无统计学意义(P>0.05)。结论协同护理模式可有效结合治疗,改善患者外周IL-17、IL-23的表达,同时具有针对性,充分调动患者的主观能动性和积极性,参与自我行为的管理和健康的决策,提高患者的生存质量,降低抑郁的发生率,因此值得临床推广使用。
Objective To observe the effect of collaborative nursing on IL-23, IL-17 inflammatory factors and psychological and physical status in patients with ulcerative colitis. Methods From January 2013 to December 2014, 88 patients with ulcerative colitis in Zhejiang Hospital were divided into observation group and control group. The patients in two groups were treated according to the different conditions and the control group were given routine nursing. The observation group were given the coordinated nursing mode based on routine nursing. The expression of IL-17 and IL-23 in the peripheral blood in two groups before and after treatment were observed. Patients for health survey simple scale (SF-36), depression self-assessment survey. Results Compared with those before treatment, the levels of IL-17 and IL-23 in observation group and control group were significantly lower than those before treatment (P <0.05), and those in observation group were lower than those in control group after treatment (P <0.05). Compared with those before treatment, the scores of quality of life, mental health, social function, emotional function, energy, body pain, health status, physiological function and mental function in observation group and control group were significantly increased after intervention (P <0.05) After intervention, the observation group was higher than the control group after intervention (P <0.05). There was no significant difference in quality of life between the two groups before treatment (P> 0.05). Compared with pre-treatment, self-evaluation scores of depression in observation group and control group were decreased after intervention (P <0.05); self-evaluation score of depression in observation group was lower than that in control group (P <0.05) The difference was not statistically significant (P> 0.05). Conclusion Collaborative nursing model can effectively combine therapy to improve the expression of IL-17 and IL-23 in the peripheral of patients, and at the same time, it has pertinence and fully mobilizes the patients’ subjective initiative and enthusiasm, participates in the management of self-behavior and makes healthy decisions to improve the survival of patients Quality, reduce the incidence of depression, it is worth to promote clinical use.