巨噬细胞活化的概念是六十年代由MacKaness首先提出的。他发现感染致病菌(如李司特菌)后康复的动物对细胞内生长菌的非特异性抵抗力增强。后来发现,这种动物对肿瘤生长的非特异性抵抗力也明显加强。体外实验证明,被活化的巨噬细胞是这种非特异性抵抗力的效应细胞。活化的巨噬 The concept of macrophage activation was first proposed by MacKaness in the sixties. He found that non-specific resistance to intracellular growth bacteria was enhanced in animals that recovered after infection with pathogenic bacteria (such as Listeria monocytogenes). Later found that non-specific resistance of this animal to tumor growth also significantly strengthened. In vitro experiments show that activated macrophages are non-specific resistance effector cells. Activated macrophages