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子宫内膜癌是妇科常见的恶性肿瘤之一,近年来发病率有上升趋势。子宫内膜癌与宫颈癌比例已由50年代的1:5～10变为1:3或1:1,甚至有发生1:1.5倒置现象。虽然通过B超、诊断性刮宫及宫腔镜等方法,可使大多数患者得到早期诊断及治疗,但仍有部分患者就诊时已为晚期。1998年Michael等报道美国白种人子宫内膜癌的发病率达22/10万,Ⅲ期及Ⅳ期各占7%及4%,美国黑人的发病率方15/10万,Ⅲ期及Ⅳ期各占12%。通过以手术为主和放疗、化疗及内分泌治疗为辅的治疗方案,早期子宫内膜癌可获得较为满意的治疗效果,Ⅰ、Ⅱ期5年生存率可超过90%,而晚期子宫内膜癌的预后明显差于早期者,5年生存率不足30%。如何正确评估并改善晚期子宫内膜癌患者的预后,选择最佳的治疗方案,提高其生存率,是妇科肿瘤领域的一个重要问题。现将近年有关晚期子宫内膜癌治疗
Endometrial cancer is one of the common gynecological malignant tumors, the incidence in recent years there is an upward trend. The ratio of endometrial cancer to cervical cancer has changed from 1: 5-10 in the 1950s to 1: 3 or 1: 1, and even 1: 1.5 inversion occurs. Although by B-mode, diagnostic curettage and hysteroscopy and other methods, most patients can be early diagnosis and treatment, but some patients are already treated for advanced stage. In 1998, Michael et al. Reported that the incidence of endometrial cancer in white people in the United States reached 22 / 100,000, with 7% and 4% in stage III and IV, 15 / 100,000 in African American, Each account for 12%. Through surgery-based and radiotherapy, chemotherapy and endocrine therapy supplemented by the treatment program, early endometrial cancer can get more satisfactory treatment, Ⅰ, Ⅱ 5-year survival rate can exceed 90%, while advanced endometrial cancer The prognosis was significantly worse than in the early, 5-year survival rate of less than 30%. How to correctly evaluate and improve the prognosis of patients with advanced endometrial cancer, select the best treatment and improve their survival rate, is an important issue in the field of gynecologic oncology. In recent years, the treatment of advanced endometrial cancer