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目的通过对50例糖尿病微量蛋白和Ⅳ型胶原的监测分析,旨在提高医技人员早期发现肾损害的诊治水平。方法采用免疫比浊法测定尿中微量蛋白,采用竞争抑制性酶联免疫吸附试验测定尿Ⅳ型胶原,将数据与正常人群对照。结果糖尿病组尿微量蛋白和Ⅳ型胶原都比正常人群高。结论检测尿微量蛋白和Ⅳ型胶原可早期发现肾损害,若及时治疗能够逆转,防止肾病发生。
Objective To monitor and analyze 50 cases of diabetic microalbumin and type Ⅳ collagen in order to improve the diagnosis and treatment of early detection of renal damage by medical technicians. Methods Urinary microalbumin was determined by immunoturbidimetry and urinary type Ⅳ collagen was determined by competitive inhibition enzyme-linked immunosorbent assay (ELISA). The data were compared with those in normal subjects. Results Urinary microalbuminuria and type Ⅳ collagen were higher than normal population. Conclusion Detection of urinary microalbumin and collagen type Ⅳ early detection of renal damage, if timely treatment can be reversed to prevent the occurrence of nephropathy.