1946年 Lücké报道了暴发性肝衰竭(fulminant hepatic failure,FHF)患者可伴发脑水肿。近年来临床工作者逐渐意识到脑水肿是FHF 最常见的合并症,1969年 Pirola 氏认为脑水肿是导致 FHF 迅即死亡之主要因素。1958～1970年美国 Dallas 州报道 FHF 53例,其中32例曾作尸检,内伴发脑水肿者16例占50%,该组病例中4例为小脑扁桃疝形成,8例为钩迥疝。Silk、鸟居正男等6篇关于FHF 的报道中,脑水肿之发生率分别为70%～82%或24%～30%。现将 FHF 伴发脑 Lücké in 1946 reported that patients with fulminant hepatic failure (FHF) may develop cerebral edema. In recent years, clinicians have come to realize that cerebral edema is the most common complication of FHF. In 1969, Pirola believed that brain edema was the main factor leading to the rapid death of FHF. From 1958 to 1970 Dallas state reported 53 cases of FHF, of which 32 cases were autopsy, accompanied by cerebral edema in 16 cases accounted for 50% of the cases in 4 cases of cerebellar almond herniation, 8 cases of hook hernia. Silk, Torii Masato and other six articles on FHF, the incidence of cerebral edema were 70% to 82% or 24% to 30%. Now FHF with brain