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目的探讨脑活素联合丹参注射液对新生儿缺血缺氧性脑病(HIE)的早期干预作用及对预后的影响。方法随机选取大埔县人民医院2007年12月至2012年2月诊治的新生儿缺血缺氧性脑病患儿80例,随机分两组,对照组40例给予吸氧、脱水及控制惊厥等对症支持治疗;治疗组40例在对照组基础上给予脑活素联合丹参注射液治疗,观察两组的临床疗效及神经症状恢复时间。结果治疗组的临床总有效率达为95%,显著高于对照组的80%,差异有统计学意义(P<0.05);治疗组的意识恢复、反射恢复及肌张力恢复时间均明显短于对照组,两组比较差异有统计学意义(P<0.05)。结论脑活素联合丹参注射液治疗新生儿缺血缺氧性脑病的疗效显著,患儿神经行为恢复快,预后好。
Objective To investigate the early intervention of cerebrolysin and Salvia miltiorrhiza on neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on prognosis. Methods Eighty children with neonatal hypoxic-ischemic encephalopathy diagnosed and treated in Dapu County People’s Hospital from December 2007 to February 2012 were randomly divided into two groups. The control group received oxygenation, dehydration and seizure control Symptomatic and supportive treatment; 40 cases in the treatment group were given combined treatment of cerebrolysin and Salvia miltiorrhiza on the basis of the control group, and the clinical efficacy and recovery time of neurological symptoms were observed. Results The total effective rate of the treatment group was 95%, significantly higher than 80% of the control group, the difference was statistically significant (P <0.05); the recovery of consciousness, reflex recovery and muscle tone recovery time were significantly shorter The control group, the difference between the two groups was statistically significant (P <0.05). Conclusion Cerebrolysin combined with Salvia injection treatment of neonatal hypoxic-ischemic encephalopathy has a significant effect, children with rapid recovery of neurological behavior, good prognosis.