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目的:探讨基础雄激素及卵泡液雄激素水平与卵巢反应性及妊娠结局的关系。方法:选取行IVF/ICSI助孕治疗的130例不孕症女性,将研究对象分为卵巢储备功能低下组、卵巢储备功能正常组。ELISA法检测基础雄激素及卵泡液中睾酮浓度。结果:卵巢储备功能低下组中,卵巢低反应组与正常反应组的基础雄激素水平比较,差异有统计学意义(P=0.037);两组卵泡液中雄激素水平比较,差异无统计学意义(P=0.475)。卵巢储备功能正常组中,卵巢低反应组与正常反应组的基础雄激素水平及卵泡液雄激素水平比较,差异均无统计学意义(P=0.426,P=0.594)。20例进行新鲜周期移植的卵巢储备功能低下患者中,未妊娠组与妊娠组基础雄激素水平及卵泡液中雄激素水平比较,差异均无统计学意义(P=0.400,P=0.656)。89例进行新鲜周期移植的卵巢储备功能正常患者中,未妊娠组与妊娠组的基础雄激素水平及卵泡液中雄激素水平比较,差异均无统计学意义(P=0.380,P=0.930)。结论:卵巢储备功能低下患者,基础雄激素水平与卵巢反应性相关,而与妊娠结局无关;卵泡液中雄激素水平与卵巢反应性和妊娠结局无关。卵巢储备功能正常患者,基础雄激素和卵泡液中雄激素均与卵巢反应性及妊娠结局无关。
Objective: To investigate the relationship between the level of androgen in basal androgen and follicular fluid and ovarian response and pregnancy outcome. Methods: A total of 130 infertile women who underwent IVF / ICSI assisted pregnancy were selected and divided into ovarian reserve deficient group and normal ovarian reserve group. Testosterone levels in basal androgens and follicular fluid were measured by ELISA. Results: There was a significant difference in basal androgen levels between ovarian low response group and normal reaction group (P = 0.037). There was no significant difference between the two groups in the level of androgen in follicular fluid (P = 0.475). In the normal ovarian reserve group, there was no significant difference between basal androgen levels and follicular fluid androgens in ovarian low reaction group and normal reaction group (P = 0.426, P = 0.594). Among the 20 patients with ovarian reserve deficient in fresh-cycle transplantation, there was no significant difference between basal androgen levels in non-pregnant group and pregnancy group and in androgen levels in follicular fluid (P = 0.400, P = 0.656). Among the 89 patients with normal ovarian reserve who had fresh-cycle transplantation, the difference was not statistically significant between basal androgen levels in non-pregnant group and pregnancy group and in androgen levels in follicular fluid (P = 0.380, P = 0.930). CONCLUSIONS: In patients with poor ovarian reserve, basal androgen levels correlate with ovarian response but not with pregnancy outcomes; and androgen levels in follicular fluid are not associated with ovarian response and pregnancy outcomes. Patients with normal ovarian reserve, basal androgens and androgen in follicular fluid were independent of ovarian response and pregnancy outcome.