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目的探讨蒙汉不同民族高尿酸血症(HUA)与代谢综合征(SM)及其组成成分的相关性。方法从健康检查人群中随机选取蒙古族、汉族SM和非SM 667例,根据SM的诊断标准,选取汉族SM 183例,蒙古族SM 145例,检测血尿酸(SUA)以及身高、体重、体重指数(BMI)、血压、血糖、血脂、瘦素(LEP)、胰岛素(Fins)和胰岛素抵抗指数(HOMA-IR)。结果蒙古族SM和非SM组的收缩压、舒张压、空腹血糖、甘油三脂、低密度脂蛋白胆固醇、SUA、Fins和HOMA-IR相比,差异均有统计学意义(P<0.05)。蒙古族SM和非SM组的BMI、总胆固醇、高密度脂蛋白胆固醇和LEP相比,差异无统计学意义(P>0.05)。SM、高血压、肥胖、高血脂的发生率随SUA水平的增加而增高,蒙古族SM的发生率在不同尿酸水平组分别为23%、38%、58%、81%。结论 SUA与SM密切相关,HUA在蒙古族SM的形成与发展中起重要作用。
Objective To investigate the relationship between HUA and metabolic syndrome (SM) and its components in different ethnic groups in Mongolia and Han nationality. Methods Mongolian and Han nationality SM and non-SM 667 cases were randomly selected from the health check-up population. According to the diagnostic criteria of SM, 183 Han patients and 145 Mongolian patients were selected to detect serum uric acid (SUA), as well as height, weight, body mass index (BMI), blood pressure, blood glucose, blood lipids, leptin (LEP), insulin (Fins) and insulin resistance index (HOMA-IR). Results The differences of systolic blood pressure, diastolic blood pressure, fasting blood glucose, triglyceride, low density lipoprotein cholesterol, SUA, Fins and HOMA-IR between Mongolian SM and non-SM groups were statistically significant (P <0.05). Mongolian SM and non-SM group BMI, total cholesterol, high-density lipoprotein cholesterol and LEP compared, the difference was not statistically significant (P> 0.05). The prevalence of SM, hypertension, obesity and hyperlipidemia increased with the increase of SUA level. The incidence of Mongolian SM was 23%, 38%, 58% and 81% in different levels of uric acid. Conclusion SUA is closely related to SM, HUA plays an important role in the formation and development of Mongolian SM.