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近年来,一些研究发现,GBV-C/HIV共感染可延缓HIV感染疾病的进程,然而也有一些研究得出不同的结论。本研究收集我国安徽省阜阳市HIV血清学阳性的既往献血员血浆标本,对其进行GBV-C感染的检测,研究GBV-C/HIV共感染与HIV病毒载量和CD4+T淋巴细胞绝对计数的关系。用RT-PCR和酶联免疫法检测,在203人中检出GBV-C感染52例,显示该人群GBV-C的感染率为25.6%,男性感染者(35例,67.3%)高于女性感染者(17例,32.7%)。分析发现,GBV-C感染与未感染两组患者的CD4+T淋巴细胞绝对计数和HIV病毒载量数据均无统计学差异。本研究中的HIV-1感染者均未接受ART治疗,因而排除了治疗对疾病进展的影响。研究结果显示,在HIV-1感染晚期的献血人群,GBV-C/HIV共感染对CD4细胞和病毒复制水平无显著影响。由于本研究对象中无HIV-1早期感染者,因而不能判断GBV-C在HIV-1感染的早期对疾病进展有无影响。
In recent years, some studies have found that co-infection with GBV-C / HIV delays the progression of HIV-infected diseases. However, some studies have drawn different conclusions. In this study, HIV seropositive past blood donor plasma samples from Fuyang City of Anhui Province were collected and tested for GBV-C infection. The co-infection of GBV-C / HIV with HIV viral load and absolute CD4 + T lymphocyte count Relationship. The results of RT-PCR and enzyme-linked immunosorbent assay showed that 52 cases of GBV-C infection were detected in 203 people, which showed that the infection rate of GBV-C in this population was 25.6% and that of male patients (35.3%, 67.3%) was higher than that of women Infection (17 cases, 32.7%). Analysis found no significant difference in absolute counts of CD4 + T lymphocytes and HIV viral load between GBV-C infected and non-infected patients. None of the HIV-1 infected individuals in this study received ART treatment, thus excluding the impact of treatment on disease progression. The results of the study showed that GBV-C / HIV co-infection had no significant effect on CD4 cell and viral replication levels in blood donors who were late in HIV-1 infection. Since there was no early HIV-1 infection in this study, it can not be determined whether GBV-C affects the progression of the disease early in HIV-1 infection.