论文部分内容阅读
充血性心力衰竭患者１０４例（正在使用地高辛加排钾利尿剂）随机均分为氯化钾缓释片（Ｓｌｏｗ－Ｋ）及普通氯化钾片（ＲＫＣｌ）２组进行保钾治疗２ｗｋ，而后改换进入另１组作自身对照。结果：Ｓｌｏｗ－Ｋ组治疗１ｗｋ末血钾即显著增加，服药承受性较好；ＲＫＣｌ组治疗２ｗｋ末血钾才显著增加，且服药承受性较差，不良反应高达２６．９％。＊Ｐ＜０．０１。±２８９ｍｇ／ｄ）。在验证过程中所用利尿剂剂量不变。３观察项目服药前测血钾（Ｋ）、钠（Ｎａ）、氯（Ｃｌ）、肌酐（Ｃｒ）、尿素氮（ＢＵＮ）和心电图。服药后每１ｗｋ复查Ｋ，Ｎａ，Ｃｌ和心电图，每２ｗｋ加复查Ｃｒ和ＢＵＮ。结果Ｓｌｏｗ－Ｋ组１０４例患者全部完成研究。ＲＫＣｌ组在研究过程中共脱落１３例（其中坚持出院者３例，心衰严重救治无效而死亡３例，因胃肠道不良反应难以耐受而改服Ｓｌｏｗ－Ｋ导致研究中断者７例），故能完成统计分析者为９１例。血清电解质治疗前后的变化２组治疗前的血Ｋ＋参数总体看来尚属正常范围，可能是由于在住院后短时间内测定血Ｋ＋，．所用排Ｋ＋利尿剂时间不长的关系。其中只有５例的血Ｋ＋在２－３ｍｍｏｌ／Ｌ的低水平。加服Ｓｌｏｗ－Ｋ片或ＲＫＣｌ片后，均能有效地使患者的血Ｋ＋提升?
104 patients with congestive heart failure (being treated with digoxin plus potassium-releasing diuretics) were randomly divided into 2 groups: potassium chloride slow-release tablets and ordinary potassium chloride tablets (RKCl) , Then change into another group as their own control. Results: In the group of Slow-K, the level of serum potassium increased significantly at the end of 1wk, and the medication was well tolerated. In the group of RKCl, the level of serum potassium increased significantly at the end of 2wk, and the medication tolerance was poor. The adverse reactions were as high as 26.9%. * P <0.01. ± 289 mg / d). The dose of diuretic used in the validation is unchanged. 3 To observe the blood potassium (K), sodium (Na), chloride (Cl), creatinine (Cr), blood urea nitrogen (BUN) and ECG before medication. After taking the drug review every 1wk K, Na, Cl and ECG, check every 2wk Cr and BUN. Results In the Slow-K group, 104 patients completed the study. In the RKCl group, 13 cases were excreted in the course of the study (3 cases were insisted on discharge, 3 cases died due to severe heart failure treatment, 7 cases were discontinued due to slow-K due to unacceptable gastrointestinal adverse reactions) It can complete the statistical analysis of 91 cases. Changes in serum electrolytes before and after treatment The blood K + parameters before treatment in the two groups generally appear to be within the normal range, probably due to the determination of blood K +, shortly after hospitalization. Used row K + diuretic time is not long relationship. Only 5 cases of blood K + 2-3mmol / L low level. Plus take Slow-K tablets or RKCl tablets, can effectively make the patient’s blood K + increase?