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目的探讨高敏C反应蛋白(hs-CRP)、B型钠尿肽(BNP)、心肌肌钙蛋白I(c Tn I)联合检测在急性心肌梗死(AMI)患者中的临床意义。方法收集南昌大学第二附属医院收治193例首发AMI患者,分别测定静脉血hs-CRP、BNP及c Tn I水平,并分析三项指标的水平变化与住院和随访期发生主要心血管事件(MACE)的关系。结果 AMI患者CRP的中位数为8.35 mg/L,BNP的中位数为267.67 pg/ml,c Tn I的中位数为13.74 ng/ml,随各单项值升高,MACE的发生率均明显升高(P<0.01),病程短者MACE的发生率较病程长者明显增多(P<0.05)。结论 CRP、BNP及c Tn I水平与AMI患者病情和预后密切相关,联合检测可提高确诊率。
Objective To investigate the clinical significance of combined detection of hs-CRP, BNP and cTn I in patients with acute myocardial infarction (AMI). Methods Ninety-three patients with AMI were enrolled in the Second Affiliated Hospital of Nanchang University. The levels of hs-CRP, BNP and cTn I in the venous blood were measured. The changes of the three indexes were analyzed and compared with those of the primary cardiovascular events (MACE )Relationship. Results The median CRP of AMI patients was 8.35 mg / L, the median of BNP was 267.67 pg / ml and the median of cTn I was 13.74 ng / ml. The incidences of MACE increased with the individual values (P <0.01). The incidence of MACE in patients with shorter duration of disease was significantly higher than that in elderly patients with disease duration (P <0.05). Conclusions The levels of CRP, BNP and cTnI are closely related to the condition and prognosis of AMI patients. Combined detection can improve the diagnosis rate.