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目的分析隆回县疑似预防接种异常反应(AEFI)的发生特征及监测系统运转情况,评价监测系统运转灵敏性及预防接种疫苗的安全性。方法采用描述性流行病学方法对隆回县2012~2014年报告的AEFI个案进行分析。结果全县2012~2014年共报告AEFI个案207例,发生率为12.11/10万。病例主要集中在<5岁,占89.37%(185例)。AEFI个案以一般反应为主,共159例,占76.81%;异常反应45例,占21.74%;偶合症3例,占1.45%。21种有不良反应报告的疫苗中,AEFI发生构成比排前3位的依次是百白破疫苗、Hib疫苗、乙脑减毒活疫苗,分别为33.82%、7.73%、7.24%。结论 AEFI监测系统运转情况良好,疫苗的安全性较好。
Objective To analyze the occurrence characteristics of AEFI and the operation of monitoring system in Longhui County, evaluate the operational sensitivity of monitoring system and the safety of vaccination. Methods A descriptive epidemiological method was used to analyze the AEFI cases reported in Longhui county from 2012 to 2014. Results A total of 207 cases of AEFI were reported in the county from 2012 to 2014, with an incidence of 12.11 / 100,000. The cases mainly concentrated in <5 years old, accounting for 89.37% (185 cases). AEFI cases were mainly general reactions, a total of 159 cases, accounting for 76.81%; abnormal reaction in 45 cases, accounting for 21.74%; 3 cases of coupling syndrome, accounting for 1.45%. Of 21 kinds of vaccine with adverse reaction reports, the composition of AEFI ranked the top three in the order of Baipi broken vaccine, Hib vaccine and JE attenuated live vaccine, which were 33.82%, 7.73% and 7.24% respectively. Conclusion The AEFI monitoring system is in good condition and the safety of the vaccine is good.