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自闭症是一种遗传相关的神经系统发育性疾病,患者会表现出社交行为障碍、重复性刻板行为等异常。在导致自闭症的众多基因中,甲基化Cp G岛结合蛋白2基因(methyl-Cp G binding protein 2,MECP2)是一个具有特殊性质的基因,当MECP2失活时会导致瑞特综合征;而当MECP2过表达时则会导致MECP2倍增综合征。通过慢病毒注射的方法,研究人员成功建立了一种神经特异性过表达MECP2的转基因食蟹猴模型,该模型表现出重复性刻板行为以及社交行为障碍等一系列与自闭症类似的表征,并且外源基因的插入和社交异常能够遗传到通过精巢移植产生的子代上。该模型为自闭症的深度研究提供了坚实基础,并为自闭症的临床治疗提供了良好的实验平台。
Autism is a genetically related neurodevelopmental disorder in which patients exhibit disorders such as social behaviors and repetitive stereotyped behaviors. Among many genes that cause autism, methyl-Cp G binding protein 2 (MECP2) is a gene of special character that causes Reiter’s syndrome when MECP2 is inactivated ; When MECP2 overexpression will result in MECP2 doubled syndrome. Through lentivirus injection, researchers successfully established a transgenic model of neuron-specific MECP2-overexpressing cynomolgus monkeys that showed repetitive stereotypes and social-behavioral impairments similar to those of autism, And insertion of exogenous genes and social abnormalities can be inherited to progeny generated by testes transplantation. The model provides a solid foundation for further research on autism and provides a good experimental platform for the clinical treatment of autism.