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目的探究阿卡波糖治疗预混胰岛素血糖控制不佳的糖尿病患者的临床疗效。方法选取2012年6月—2014年1月在清远市清城区洲心社区卫生服务中心接受治疗的预混胰岛素血糖控制不佳的糖尿病患者120例。根据患者不同的治疗方案将患者分为观察组和对照组,每组60例。对照组采用常规方案治疗,观察组在常规治疗的基础上加用阿卡波糖治疗。比较两组患者治疗前和治疗后12周的空腹血糖、餐后血糖、空腹C肽、餐后C肽及糖化血红蛋白(Hb A1c)。结果两组患者治疗前空腹血糖、餐后血糖、空腹C肽、餐后C肽及Hb A1c比较,差异均无统计学意义(P>0.05);治疗后12周,观察组患者的空腹血糖、餐后血糖、空腹C肽、餐后C肽及Hb A1c均低于对照组(P<0.05)。结论阿卡波糖治疗预混胰岛素血糖控制不佳的糖尿病患者的临床效果显著,可有效改善患者的血糖控制,提高患者的生活质量。
Objective To investigate the clinical efficacy of acarbose in the treatment of patients with diabetes with poorly controlled blood glucose. Methods From June 2012 to January 2014, 120 patients with poorly controlled glycemic control of premixed insulin underwent treatment in Chau Heart Community Health Service Center, Qingcheng District, Qinghai. Patients were divided into observation group and control group according to different treatment plans of patients, 60 cases in each group. The control group was treated with conventional regimen. The observation group was given acarbose on the basis of routine treatment. Fasting blood glucose, postprandial blood glucose, fasting C-peptide, postprandial C-peptide and Hb A1c were compared between the two groups before and 12 weeks after treatment. Results There was no significant difference in fasting blood glucose, postprandial blood glucose, fasting C-peptide, postprandial C-peptide and Hb A1c between the two groups before treatment (P> 0.05). After 12 weeks of treatment, the fasting blood glucose, Postprandial blood glucose, fasting C-peptide, postprandial C-peptide and Hb A1c were lower than those in the control group (P <0.05). Conclusion Acarbose treatment of premixed insulin poor glycemic control of patients with significant clinical effects of diabetes can effectively improve the patient’s blood glucose control and improve patient quality of life.