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目的分析2010年南京地区呼吸道感染患儿的肺炎支原体(MP)感染流行病学特征。方法呼吸道感染患儿8685例,按年龄分为A组(1d~,878例)、B组(29d~,3307例)、C组(1岁~,2069例)、D组(3岁~,1558例),E组(6岁-14岁11个月,873例)。采用FQ-PCR法对患儿呼吸道分泌物标本进行MP-DNA检测。MP-DNA阳性患儿中,上呼吸道感染23例(F组),下呼吸道感染2731例(G组),比较两组MP-DNA拷贝数log值。结果女性患儿MP-DNA阳性率高于男性患儿(38.15%vs.31.33%)(P<0.01),C、D组女性患儿MP-DNA阳性率均高于男性患儿(P<0.01或P<0.05),不同年龄组MP-DNA阳性率比较有统计学差异(P<0.01)。夏、秋季患儿MP-DNA阳性率高于春、冬季患儿(43.63%、47.01%vs.27.64%、20.68%)(P<0.05)。A、B、C和D组内患儿四季MP-DNA阳性率比较有统计学差异(P<0.01)。G组MP-DNA拷贝数log值高于F组(5.74±1.42vs.4.71±1.25)(P<0.01)。结论南京地区呼吸道感染患儿MP感染存在性别差异,学龄前期和学龄期为儿童MP感染高发年龄,夏、秋季为本地区MP感染高发季节。
Objective To analyze the epidemiological characteristics of Mycoplasma pneumoniae (MP) infection in children with respiratory tract infection in Nanjing in 2010. Methods A total of 8685 children with respiratory tract infection were divided into three groups according to their ages: group A (1d ~ 878), group B (29d ~, 3307cases), group C (1 ~ 2069cases), group D 1558 cases), Group E (6-year-old 11-month, 873 cases). FQ-PCR method was used to detect respiratory secretions in children with MP-DNA. Among the MP-DNA-positive children, 23 cases of upper respiratory tract infection (group F) and 2731 cases of lower respiratory tract infection (group G). The MP-DNA copy number log was compared between the two groups. Results The positive rate of MP-DNA in female children was higher than that in male children (38.15% vs.31.33%) (P <0.01). The positive rates of MP-DNA in female children in groups C and D were higher than male children Or P <0.05). The positive rates of MP-DNA in different age groups were statistically different (P <0.01). The positive rate of MP-DNA in summer and autumn was higher than that in spring and winter (43.63%, 47.01% vs.27.64%, 20.68%) (P <0.05). The positive rates of MP-DNA in four seasons in groups A, B, C and D were statistically different (P <0.01). The log-value of MP-DNA copy number in group G was higher than that in group F (5.74 ± 1.42 vs 4.71 ± 1.25) (P <0.01). Conclusions There are gender differences in MP infection in children with respiratory tract infection in Nanjing. The incidence of MP infection is high in preschool children and school-age children, and the highest incidence of MP infection in summer and autumn in this area.