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目的:探讨广西新发现肝癌高发点乙型肝炎病毒(HBV)、丙型肝炎病毒(HCV)感染在肝癌家族聚集性中的作用。方法:在广西新发现的肝癌高发点选择发生2例以上肝癌病例的高发家族成员作为研究对象,并选择性别和年龄构成相同的无癌家族成员作为对照,应用ELISA法检测HBV和HCV血清学标志物,采用PCR和RT-PCR技术对HBVDNA和HCVRNA进行检测。结果:在肝癌高发家族和无癌家族两组成员中HBsAg、HBsAb、HBeAg、HBVDNA的阳性率分别为24.47%、35.11%、8.51%、14.89%和8.51%、53.19%、4.26%、4.26%,HBsAg、HBsAb和HBVDNA在两组间存在显著性差别,P值分别为0.003、0.012、0.013;而HBeAg在两组间无显著性统计学意义(P>0.05);两组均未发现HCV-Ab和HCVRNA阳性者。结论:广西新肝癌高发点的肝癌家族聚集性的主要危险因素可能是HBV的感染和遗传因素的共同作用;HCV的感染与此高发点的家族聚集性无关。
Objective: To investigate the role of newly discovered hepatocellular carcinoma (HBV) and hepatitis C virus (HCV) in newly diagnosed HCC patients in Guangxi province. Methods: Two high-risk cases of HCC were selected as the research object in the newly discovered high incidence of HCC in Guangxi. The members of the same cancer-free family members were selected as controls. Serological markers of HBV and HCV were detected by ELISA The HBV DNA and HCV RNA were detected by PCR and RT-PCR. Results: The positive rates of HBsAg, HBsAb, HBeAg and HBVDNA were 24.47%, 35.11%, 8.51%, 14.89% and 8.51%, 53.19%, 4.26% and 4.26% respectively in the two groups with high incidence of HCC and non-HCC, HBsAg, HBsAb and HBVDNA in the two groups were significantly different, P values were 0.003,0.012,0.013; HBeAg was no significant difference between the two groups (P> 0.05); no HCV-Ab And HCV RNA positive. Conclusion: The main risk factors of familial aggregation of hepatocellular carcinoma in new-onset hepatocellular carcinoma in Guangxi may be the combination of HBV infection and genetic factors. HCV infection has no relation with this high incidence of familial aggregation.