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辅助生殖技术(assisted reproductive technology,ART)的开展解决了许多不孕夫妇的生育需求,随着ART中新技术的开展和子代人数的增加,ART的安全性引起更多关注。综述ART与多种妊娠期并发症及不良产科结局的关系,提示经ART妊娠女性发生妊娠期高血压疾病、产科出血、妊娠期糖尿病的风险升高,ART子代发生早产、低出生体质量及出生缺陷风险升高。其机制目前尚不明确,潜在的不孕背景可能是引起不良产科结局的原因之一。对于经ART妊娠妇女,应重视其围生期保健并提供必要的产前筛查及诊断以改善母婴预后。
The development of assisted reproductive technology (ART) has solved the fertility needs of many infertile couples. With the development of new technologies in ART and the increasing number of offspring, the safety of ART has attracted more attention. The relationship between ART and various complications of pregnancy and poor obstetric outcomes is summarized. It is suggested that the risk of gestational hypertension, obstetric bleeding and gestational diabetes is increased in ART pregnant women. ART progeny have preterm birth, low birth weight, Risk of birth defects increased. The mechanism is not yet clear, the potential infertility background may be one of the causes of adverse obstetric outcomes. For ART pregnant women, attention should be paid to their perinatal care and to provide the necessary prenatal screening and diagnosis to improve mother-infant outcomes.