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近来发现,转移淋巴结被膜外侵犯为恶性肿瘤预后的重要因素,然而结直肠癌TNM分期系统未将其作为预后参数。为了确定被膜外侵犯在淋巴结阳性结直肠癌中的预后作用,Veronese N等纳入30个研究包括1 336例患者分为是否有被膜外侵犯进行分析,平均随访4.7年。结果发现,淋巴结被膜外侵犯与全因死亡率有关(HR=1.75;95%可信区间:1.42~2.16,P<0.000 1,I~2=60%;HR=1.69,95%可信区间:1.32~2.17,P<0.000 1,I~2=46%),与疾病复发率也有关(RR=2.07,95%可信区间:
Recently, it has been found that the invasion of metastatic lymph nodes outside the capsule is an important factor in the prognosis of malignant tumors, however, the TNM staging system for colorectal cancer has not been used as a prognostic parameter. To determine the prognostic role of extranodal invasion in lymph node-positive colorectal cancer, Veronese N et al. Included 30 studies including 1 336 patients classified as extra-membranous invasion for an average follow-up of 4.7 years. The results showed that extranodal invasion of lymph nodes was associated with all-cause mortality (HR = 1.75; 95% CI: 1.42-2.16, P <0.0001, I ~ 2 = 60%; HR = 1.69, 95% confidence interval: 1.32 to 2.17, P <0.0001, I to 2 = 46%) were also associated with disease recurrence rates (RR = 2.07, 95% confidence interval: