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目的:探索黑斑-息肉综合征(Peutz-Jeghers syndrome,PJS)的临床诊治。方法:对2000/2008年收治的黑斑-息肉综合征患者17例进行分析。结果:本组中有典型黑斑和息肉12例,14例有3枚以上息肉,3例3个以下息肉中2例并有典型黑斑,1例有PJS家族史;15例为结肠息肉,其中2例伴有小肠息肉,2例伴有胃息肉,2例单纯为胃十二指肠息肉。经胃肠镜下摘除14例,外科手术治疗1例,均无并发症发生。6例术后复发;1例复查发现癌变。结论:PJS在诊断上应综合考虑临床症状、家族史、详细的体格检查和胃肠镜全消化道检查,以免误诊和漏诊;临床治疗上以胃肠镜下摘除为主,也可考虑外科手术治疗,治疗后应定期复查及随访。
Objective: To explore the clinical diagnosis and treatment of Peutz-Jeghers syndrome (PJS). Methods: Seventeen patients with melasma-polyposis syndrome who were treated in 2000/2008 were analyzed. Results: There were 12 cases of typical black spot and polyp in this group, 14 cases had more than 3 polyps, 3 cases of 3 following polyps in 2 cases and typical dark spots, 1 case had PJS family history; 15 cases of colon polyps, Among them, 2 cases were accompanied by small intestine polyps, 2 cases were associated with gastric polyps, and 2 cases were simply gastroduodenal polyps. 14 cases were removed by gastrointestinal endoscopy and 1 case was treated by surgery. No complication occurred. 6 cases of recurrence; 1 case of re-found cancerous. Conclusion: The diagnosis of PJS should be comprehensive consideration of clinical symptoms, family history, detailed physical examination and gastrointestinal endoscopy, so as to avoid misdiagnosis and missed diagnosis; clinical treatment of gastrointestinal endoscopic removal may also consider surgery Treatment, treatment should be regularly reviewed and followed up.