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低氧性肺动脉高压(hypoxic pulmonary hypertension,HPH)的发病机制目前还不十分清楚。近年来越来越多的研究发现,钙敏感受体(calcium sensing receptor,CaSR)参与了HPH的发生和发展。研究表明,肺动脉平滑肌细胞(pulmonary artery smooth muscle cells,PASMCs)可表达CaSR,CaSR对PASMCs中钙浓度的变化、肺血管紧张度的调节与PASMCs增殖发挥着重要作用,因此,CaSR的研究可为阐明HPH发病机制提供一个新的方向,本文简要介绍了CaSR参与HPH形成的研究进展。
The pathogenesis of hypoxic pulmonary hypertension (HPH) is not yet clear. In recent years, more and more studies have found that calcium sensing receptor (calcium sensing receptor, CaSR) involved in the occurrence and development of HPH. Studies have shown that pulmonary arterial smooth muscle cells (PASMCs) can express CaSR. CaSR plays an important role in the changes of calcium concentration in PASMCs, the regulation of pulmonary vascular tone and the proliferation of PASMCs. Therefore, the study of CaSR may be clarified HPH pathogenesis provides a new direction, this article briefly introduces the CaSR involved in the formation of HPH research progress.