论文部分内容阅读
本实验主要观察蝙蝠葛碱大、中、小剂量对大白鼠心、肝、肾及肾上腺的亚急性毒性影响。该药4.8～600mg剂量用药18天或2～3月,对心脏无不良影响。150mg以上剂量用药2～3月对肝脏有不同程度的损害,受损程度随剂量增大而加重,150mg所致的损害是轻度的,75mg以下无不良影响。300mg以上对肾有轻度损害,150mg以下对肾和肾上腺基本无不良影响。按蝙蝠葛碱的降压和抗心律失常有效量计算,该药只对肝脏有轻度损害作用。
This experiment mainly observed the subacute toxic effects of daphragine alkaloids on heart, liver, kidney and adrenal glands in rats. The drug 4.8 ~ 600mg dose medication for 18 days or 2 to 3 months, no adverse effects on the heart. More than 150mg dose of medication 2 to 3 months of varying degrees of damage to the liver, the extent of damage with the increase of the dose, 150mg damage caused by mild, 75mg or less no adverse effects. More than 300mg had slight damage to the kidney, and 150mg had no adverse effects on the kidney and adrenal glands. According to the effective amount of antihypertensive and antiarrhythmic drugs of dauricine, the drug only slightly damages the liver.