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目的观察奥扎格雷钠联合尿激酶治疗脑梗死的临床效果。方法将脑梗死患者按随机化原则分为治疗组(奥扎格雷钠80mg加入5%葡萄糖溶液250ml中静脉滴注,每天1次,连用7天。同时应用尿激酶100万单位加入生理盐水250ml中静脉滴注,每天1次,连用2天)和对照组(尿激酶100万单位加入生理盐水250ml中,静脉滴注,连用2天。后用血栓通注射液20ml加入5%葡萄糖溶液250ml中静脉滴注,每天1次,连用7天作为后续治疗)。结果治疗组显效率74.3%,总有效率96.3%;对照组显效率67.9%,总有效率85.7%;两组比较P<0.05。进展性脑卒中发生率;治疗组1.2%,对照组8.9%,两组比较P<0.01。结论奥扎格雷联合尿激酶治疗脑梗死能显著改善临床症状,降低致残率,并能有效预防进展性脑卒中发生。
Objective To observe the clinical effect of ozagrel combined with urokinase on cerebral infarction. Methods According to the principle of randomization, the patients with cerebral infarction were divided into treatment group (Ozagrel sodium 80mg was added into 250ml of 5% dextrose solution by intravenous infusion once daily for 7 days.) Meanwhile, 1 million units of urokinase were added into 250ml of normal saline Intravenous infusion, once daily for 2 days) and control group (urokinase 100 million units added 250ml of normal saline, intravenous infusion, once every 2 days.After the use of thrombosis injection 20ml added 5% glucose solution 250ml medium vein Drip, 1 day, once every 7 days as a follow-up treatment). Results The effective rate of the treatment group was 74.3%, the total effective rate was 96.3%; the effective rate of the control group was 67.9%, the total effective rate was 85.7%; P <0.05. The incidence of progressive stroke was 1.2% in the treatment group and 8.9% in the control group, P <0.01. Conclusions Ozagrel combined with urokinase in the treatment of cerebral infarction can significantly improve the clinical symptoms, reduce the disability rate, and can effectively prevent the occurrence of progressive stroke.