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髓系细胞是动脉粥样硬化病变发展和易损斑块形成的核心。动脉吞噬细胞吸收凋亡细胞(胞葬作用)的能力受损,可促进病变生长并建立坏死核心。干扰素调节因子(interferon regulatory factor,IRF)5是髓系细胞功能的重要调节因子。该研究试图确定IRF5是否影响动脉粥样硬化病变的形成和表型。方法:通过两种互补模型,研究IRF5在动脉粥样硬化中的作用:
Myeloid cells are the core of the development of atherosclerotic lesions and the formation of vulnerable plaque. The ability of arterial phagocytes to absorb apoptotic cells (the role of cells) is impaired, which can promote the growth of the lesion and establish the necrotic core. Interferon regulatory factor (IRF) 5 is an important regulator of myeloid cell function. The study sought to determine whether IRF5 affects the formation and phenotype of atherosclerotic lesions. METHODS: The effects of IRF5 on atherosclerosis were studied by two complementary models: