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偏二甲基肼(UDMH)是一种可贮存的液体火箭燃料,沸点63℃,25℃饱和蒸气庄209kPa,属中等毒性化学物。吸入是职业中毒的主要途径。本文采用氨基铁氰化钠比色法测定了血、尿、吸入和呼出气中UDMH浓度的经时变化,对UDMH吸入、静注和静脉恒速输注在家兔体内的毒物动力学进行了研究。 家兔静注UDMH 39.0mg/kg,呈二室开放模型配置。分布相半减期(t_(1/2α))=2.89±2.52min,分布快。稳态表观分布容积(Vss)=1.32±0.13L/kg,分布后相中室毒量占全身毒量的分率(f_C~*)=0.33±0.12,提
Dimethylhydrazine (UDMH) is a storable liquid rocket fuel with a boiling point of 63 ° C and saturated steam of 209 kPa at 25 ° C. It is a moderately toxic chemical. Inhalation is the main route of occupational poisoning. In this paper, the concentration changes of UDMH in blood, urine, inhaled and exhaled breath were measured by the method of sodium aminotransyanide colorimetry. The toxicokinetics of UDMH inhaled, intravenously injected and intravenous constant velocity infusion in rabbits were studied the study. Rabbits intravenous UDMH 39.0mg / kg, was two-chamber open model configuration. The distribution of half-deadline (t_ (1 / 2α)) = 2.89 ± 2.52min, fast distribution. The steady state apparent volume of distribution (Vss) was 1.32 ± 0.13 L / kg, and the fraction of the total amount of poison in the chamber (f_C ~ *) was 0.33 ± 0.12