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该研究旨在研究补充Vit E对高血脂和(或)吸烟者内皮依赖血管舒张功能的影响以及对LDL氧化作用的调节。 方法 分组:采用前瞻性、随机、双盲、安慰剂对照研究。高血脂组13例,长期吸烟组13例,高血脂吸烟组15例。再按1:2的比例将每组受试者随机分为接受安慰剂治疗或Vit E治疗。经血管功能的基础测定后,受试者接受安慰剂或Vit E治疗4个月(544IU/d),再测血脂浓度、血管功能和抗氧化LDL自身抗体滴度。
The aim of this study was to investigate the effects of VitE supplementation on endothelium-dependent vasodilation in hyperlipidemic and / or smokers and the regulation of LDL oxidation. Methods Grouping: A prospective, randomized, double-blind, placebo-controlled study was performed. 13 cases of hyperlipidemia group, 13 cases of long-term smoking group and 15 cases of hyperlipidemia group. Each group of subjects was then randomized to receive either placebo or Vit E in a 1: 2 ratio. After basic measurements of vascular function, subjects received placebo or Vit E for 4 months (544 IU / d), and their serum lipid concentrations, vascular function, and anti-oxidant LDL autoantibody titers were measured.