寻找肿瘤药物作用的新靶点和合成新的抗肿瘤药一直是肿瘤治疗研究的重大课题。线粒体结构和功能的改变 ,不仅会干扰肿瘤细胞的生长、代谢和增殖等过程 ,最终还会触发很多肿瘤细胞凋亡[1～ 4] 。随着线粒体调控细胞凋亡的发现 ,线粒体诱导肿瘤细胞凋亡成为目前研究的新热点。最 Looking for the new target of tumor drugs and the synthesis of new antineoplastic agents have always been a major issue in cancer therapy research. Changes in mitochondrial structure and function not only interfere with the growth, metabolism and proliferation of tumor cells, but also trigger many apoptosis of tumor cells [1-4]. With the discovery of mitochondria regulating apoptosis, mitochondria induced tumor cell apoptosis has become a new hot spot in the current research. most