曲马多是一种阿片受体激动剂,为中枢神经系统镇痛药,具有双重作用机制,既可与中枢神经系统的弱阿片受体结合,又具有抑制单胺类神经递质(5-羟色胺和肾上腺素)在脊髓突触间重摄取作用。这两种作用机制在发挥镇痛效应时相互协同,增强疗效。曲马多的镇痛强度在同等剂量时,相当于吗啡的1/5,但明显强于其他非类固醇抗炎药。该药与阿片受体的亲和 Tramadol, an opioid receptor agonist, is a central nervous system analgesic with a dual mechanism of action that binds to weak opiate receptors in the central nervous system as well as inhibits monoamine neurotransmitters (5- Serotonin and epinephrine) in the spinal cord between the synaptic reabsorption. These two mechanisms of action play a synergistic role in the analgesic effect and enhance the efficacy. Analgesia intensity tramadol at the same dose, equivalent to 1/5 of morphine, but significantly stronger than other non-steroidal anti-inflammatory drugs. The drug is compatible with opioid receptors