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目的观察CC趋化因子受体1(CCR1)在急性心肌梗死(AMI)患者血浆中的表达水平。方法检测AMI组(29例)、不稳定型心绞痛(UAP)组(30例)、稳定型心绞痛(SAP)组(30例)和正常对照(C)组(25例)血常规、血脂、超敏C反应蛋白(hs-CRP)、心肌肌钙蛋白I(cTnI)、低密度脂蛋白胆固醇(LDL-C)、白细胞(WBC)、中性粒细胞比值(N),ELISA法检测血浆CCR1表达;动态观察AMI患者经皮冠状动脉介入治疗(PCI)术前、术后24、48h、5、7d的CCR1水平变化,分析CCR1与hs-CRP、cTnI、LDL-C、WBC、N比值的相关性。结果 AMI组、UAP组、SAP组血浆CRR1水平明显高于C组[(3.72±0.94)ng/ml、(2.05±0.38)ng/ml、(1.82±0.41)ng/mlvs.(0.68±0.27)ng/ml](P<0.05);AMI组血浆CCR1水平明显高于UAP组、SAP组;AMI组患者PCI术前血浆CCR1水平显著高于术后(P<0.05);血浆CCR1水平与WBC、N比值呈正相关(P<0.05)。结论 AMI组患者CCR1水平明显升高,PCI术后逐渐下降并趋于稳定;AMI组患者血浆CCR1水平与WBC、N比值呈正相关。
Objective To investigate the expression of CC chemokine receptor 1 (CCR1) in plasma of patients with acute myocardial infarction (AMI). Methods The levels of blood, blood lipids and ultrasonography in AMI group (30 cases), unstable angina pectoris group (30 cases), normal angina pectoris group (30 cases) and normal control group (C group) Plasma hs-CRP, cTnI, LDL-C, WBC, neutrophil ratio (N) were detected by enzyme linked immunosorbent assay (ELISA) . The changes of CCR1 level before and 24, 48, 5 and 7 days after percutaneous coronary intervention (PCI) were observed in patients with AMI. The correlation between CCR1 and hs-CRP, cTnI, LDL-C, Sex. Results The plasma level of CRR1 in AMI, UAP and SAP groups was significantly higher than that in C group [(3.72 ± 0.94) ng / ml, (2.05 ± 0.38) ng / ml, (1.82 ± 0.41) ng / ml vs (P <0.05). The level of plasma CCR1 in AMI group was significantly higher than that in UAP group and SAP group. The level of CCR1 in AMI group was significantly higher than that in postoperative group (P <0.05) N ratio was positively correlated (P <0.05). Conclusions The level of CCR1 in patients with AMI is significantly higher than that in patients with AMI. The level of CCR1 in AMI patients is positively correlated with the ratio of WBC and N.