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Purpose:To investigate the global cytokine and chemokine expression pattern in the aqueous humor of uveitis patients and relate them to clinical features.Design:Cross-sectional study.Methods:In 31 aqueous humor samples from uveitis patients,the concentration of mediators was measured by a multiplex immunoassay.Eleven control samples were included.Results:Uveitis samples had higher levels of interleukin-6,interleukin-8,soluble intercellular adhesion molecule,soluble vascular cell adhesion molecule(sVCAM),and interferon-inducible protein-10(IP-10)than nonuveitis controls.Active uveitis samples had higher levels of interleukin-6,interleukin-10,interferon-γ,sVCAM,regulated on activation,normal T cell expressed and secreted(RANTES),and IP-10 than quiescent uveitis samples.Infectious uveitis was associated with higher levels of interleukin-10 than noninfectious uveitis(P<.03 for all subgroups).No significant differences were found between cystoid macular edema(CME)and non-CME samples.Conclusions:Elevated levels of specific mediators were found in active and in infectious uveitis,but not in CME.Mediator profiles might lead to a better understanding of the pathogenesis of uveitis.
Purpose: To investigate the global cytokine and chemokine expression pattern in the aqueous humor of uveitis patients and relate them to clinical features. Design: Cross-section study. Methods: In 31 aqueous humor samples from uveitis patients, the concentration of mediators was measured by A multiplex immunoassay. Eleven control samples were included. Results: Uveitis samples had higher levels of interleukin-6, interleukin-8, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule (sVCAM), and interferon-inducible protein- 10) than nonuveitis controls. Active uveitis samples had higher levels of interleukin-6, interleukin-10, interferon-gamma, sVCAM, regulated on activation, normal T cell expressed and secreted (RANTES), and IP- 10 than quiescent uveitis samples. Infectious uveitis was associated with higher levels of interleukin-10 than noninfectious uveitis (P <.03 for all subgroups) .No significant differences were found between cystoid macular edema (CME) and non-CME samples. Conflu sions: Elevated levels of specific mediators were found in active and in infectious uveitis, but not in CME. Mediator profiles might lead to a better understanding of the pathogenesis of uveitis.