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目的探讨天台县肾综合征出血热(HFRS)的流行特征和发展趋势,以制定有针对性的防制措施。方法人间疫情流行病学调查,采用间接免疫荧光法检测患者及健康人群血清抗体;宿主动物带病毒调查,采用直接免疫荧光法检测鼠肺汉坦病毒(HV)抗原。结果 2005-2009年全县累计报告HFRS病例181例,年平均发病率6.39/10万;男女发病之比为2.42∶1(128/53),以农民发病为主,占86.74%;室内鼠密度平均为2.10%,野外为5.76%,总鼠密度为4.87%,鼠带病毒率平均为7.48%;患者血清阳性率为77.70%。结论天台县是以姬鼠型为主的混合型HFRS疫区,需要进一步加大监测和预防力度。
Objective To explore the epidemiological characteristics and development trend of hemorrhagic fever with renal syndrome (HFRS) in Tiantai County so as to make targeted prevention and control measures. Methods Epidemiological survey of human epidemic situation was carried out. Serum antibodies were detected by indirect immunofluorescence in patients and healthy subjects. The host animals were infected with virus and the direct immunofluorescence assay was used to detect Hantavirus (HV) antigen in mouse lung. Results A total of 181 HFRS cases were reported in the county in 2005-2009, with an average annual incidence rate of 6.39 / lakh. The incidence rate of male to female was 2.42:1 (128/53), with the incidence of peasants accounting for 86.74%. The indoor rat density Average 2.10%, wild 5.76%, total rat density 4.87%, the average rate of rat virus was 7.48%; The positive rate of patients was 77.70%. Conclusion Tiantai is a type of mixed HFRS epidemic mainly based on the Apodemus type, which requires further monitoring and prevention efforts.