论文部分内容阅读
对７０例胃癌伴癌旁胃粘膜肠化石蜡标本连续切片组织同步进行ＰＡＳ—高铁二胺—爱先蓝复合粘液染色及增殖细胞抗原（ＰＣＮＡ），Ｐ５３、Ｐ２１、ｃ－ｅｒｂＢ－２三种癌基因蛋白产物检测，结果显示：癌旁胃粘膜肠化以结肠型化生为主（８７．１％），包括不完全性结肠型化生和完全性结肠型化生。２２．９％的胃癌组织中含有与不完全性结肠型化生相同的粘液，５４．３％含有与完全性结肠型化生相同的粘液，表明胃粘膜结肠型化生与胃癌有关；小肠型化生，结肠型化生，胃癌ＰＣ－ＮＡ指数逐级升高，表明胃粘膜肠化与胃癌均有不同程度的异常增生；正常胃粘膜Ｐ５３、Ｐ２１、ｃ－ｅｒｂＢ－２不表达，小肠型化生表达阳性或弱阳性，无复合表达，不完全性结肠型化生、完全性结肠型化生、胃癌表达率、过度表达率、复合表达率逐级递增，提示胃粘膜结肠型化生作为一种癌前病变或早期胃癌的一个信号，应引起临床医生高度重视。
Simultaneous PAS-high iron-diamine-aisen blue complex mucin staining and proliferating cell antigen (PCNA), P53, P21, and c-erbB-2 cancers were serially performed on 70 paraffin-embedded specimens of gastric cancer with adjacent paragastric mucosa. The detection of gene protein products showed that the intestinal metaplasia of the adjacent gastric mucosa was mainly colonic metaplasia (87.1%), including incomplete colonization and complete colon metaplasia. 22.9% of gastric cancer tissues contained the same mucus as incomplete colon metaplasia, 54.3% contained the same mucus as the complete colon metaplasia, indicating that gastric mucosal colonization is associated with gastric cancer; small intestine type The PC-NA index increased gradually in metaplasia, colon metaplasia, and gastric cancer, indicating that gastric mucosal intestinal metaplasia and gastric cancer have different degrees of abnormal hyperplasia; normal gastric mucosal P53, P21, and c-erbB-2 do not express, small intestine type Metaplasia positive or weakly positive, no compound expression, incomplete colon metaplasia, complete colon metaplasia, gastric cancer expression rate, overexpression rate, compound expression rate progressively increasing, suggesting that gastric mucosal colon metaplasia A signal of precancerous lesions or early gastric cancer should cause clinicians to attach great importance to it.