脂肪酸合酶(fatty acid synthase,FAS)是合成脂肪酸的关键酶,其产物脂肪酸是肿瘤细胞增殖的物质和能量来源。研究发现,FAS在泌尿系肿瘤如前列腺癌、膀胱癌、肾癌、肾母细胞瘤高表达。FAS的过度表达与肿瘤的发生、演变、侵袭、预后及耐药性有关。浅蓝菌素、C75、C93、奥利司他及几种天然植物性多酚是FAS的抑制剂。研究FAS抑制剂为肿瘤化疗开辟了新的途径,为化疗药物研发提供了新的靶点。 Fatty acid synthase (FAS) is a key enzyme in the synthesis of fatty acids, and its product, fatty acid, is a substance and energy source for tumor cell proliferation. The study found that, FAS in urological tumors such as prostate cancer, bladder cancer, kidney cancer, nephroblastoma high expression. The overexpression of FAS is associated with tumorigenesis, evolution, invasion, prognosis and drug resistance. Cerulen, C75, C93, Orlistat and several natural plant polyphenols are FAS inhibitors. Research FAS inhibitors for tumor chemotherapy opened up new avenues for the development of chemotherapeutic drugs provides a new target.