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目的探讨妊娠早期母体甲状腺功能异常对妊娠结局的影响。方法 16161例建卡的孕妇,根据筛查结果将甲状腺功能异常的孕妇1131例作为研究对象,所有孕妇在妊娠期间进行疾病对症治疗,根据甲状腺功能控制情况将孕妇分为控制组(n=624)与未控制组(n=507),对两组妊娠并发症、不良结局的发生情况进行观察比较。结果在妊娠糖尿病、贫血及妊娠高血压发生率方面,未控制组与控制组比较明显提高,差异有统计学意义(P<0.05);但在胎盘早剥发生率方面,两组比较差异无统计学意义(P>0.05);在早产、流产及新生儿低体重发生率方面,未控制组与控制组比较明显提高,差异有统计学意义(P<0.05);但在胎儿窘迫发生率方面,两组比较差异无统计学意义(P>0.05)。结论妊娠早期母体甲状腺功能异常对妊娠结局具有一定的不良影响,临床应对其给予高度重视,为保障母婴健康,妊娠早期应最大程度将母体甲状腺功能控制在正常水平。
Objective To investigate the effect of maternal thyroid dysfunction on pregnancy outcome in early pregnancy. Methods According to the results of screening, 1131 pregnant women with hypothyroidism were enrolled in this study. All pregnant women were treated for symptomatic treatment during pregnancy. According to the control of thyroid function, pregnant women were divided into control group (n = 624) And uncontrolled group (n = 507). The incidence of pregnancy complications and adverse outcomes in the two groups were observed and compared. Results Compared with control group, the incidence of gestational diabetes mellitus, anemia and pregnancy-induced hypertension were significantly increased in control group and control group (P <0.05). However, there was no statistical difference in the incidence of placental abruption (P0.05) .In the premature, abortion and neonatal low birth weight rate, uncontrolled group and control group were significantly increased, the difference was statistically significant (P <0.05); but in the incidence of fetal distress, There was no significant difference between the two groups (P> 0.05). Conclusion Maternal thyroid dysfunction in early pregnancy has some adverse effects on pregnancy outcome, and should be paid great attention in clinical practice. To ensure the health of mother and baby, the maternal thyroid function should be controlled to the normal level in early gestation.