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Peyronie病以阴茎白膜局部纤维斑块形成为特征,在临床中相对少见。国内外与之相关的基础研究甚少,除疾病本身相对少见外,可能与疾病动物模型的不确定性有一定关系。目前较常用的Peyronie病动物模型各存利弊,其中转化生长因子β1(TGF-β1)与Fibrin白膜下注射缺乏阴茎弯曲、钙/骨化等特征;手术创伤可能建立Peyronie病急性期模型;自发模型则可能带来全身多组织器官纤维化与人Peyronie病表现不一等不足。模型的选择对基础研究至关重要,因此,本文通过回顾Peyronie病相关的动物研究模型,为该病基础研究提供参考。
Peyronie’s disease is characterized by local fibrous plaque formation of the penile white coat, which is relatively uncommon in the clinic. There are very few basic research related to it at home and abroad, except that the disease itself is relatively rare, which may be related to the uncertainty of the animal model of disease. At present, the most common animal models of Peyronie’s disease have their own advantages and disadvantages. Among them, TGF-β1 and Fibrin injection lack of penile curvature, calcium / ossification and other characteristics; surgical trauma may establish Peyronie disease acute model; spontaneous Model may lead to systemic multi-tissue organ fibrosis and human Peyronie disease performance is equal. The choice of model is essential to basic research. Therefore, this article reviews the Peyronie disease related animal research model and provides a reference for the basic research of the disease.