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目的探讨国产阿加曲班注射液治疗妊产妇静脉血栓形成的有效性及安全性。方法回顾性分析2005-2009年在神经科住院的16例妊产妇静脉血栓形成患者的临床资料,并结合文献分析了该病的病因、临床表现、影像学检查资料、治疗及预后等情况。结果妊产妇静脉血栓患者16例,多以头痛、恶心、呕吐、视物模糊、意识障碍、癫痫等为首发症状,可有或无神经系统定位体征。头颅CT或头颅MRI检查等多为双侧多发性脑梗死,MRV示大脑浅静脉、上矢状窦、下矢状窦、横窦等血栓。经综合治疗后除1例因高血压、糖尿病较重,引起枕叶脑出血,遗留偏瘫外余病例均完全恢复。结论国产阿加曲班注射液对妊产妇静脉血栓形成有肯定的疗效.对人体无明显的不良反应,是治疗妊产妇静脉血栓形成的安全、有效的药物。
Objective To investigate the efficacy and safety of domestic argatroban injection in the treatment of venous thrombosis in pregnant women. Methods The clinical data of 16 pregnant women with venous thrombosis who were hospitalized in neurology from 2005 to 2009 were retrospectively analyzed. The etiology, clinical manifestations, imaging examination data, treatment and prognosis of the patients were analyzed. Results In the 16 cases of pregnant women with venous thrombosis, the first symptom was headache, nausea, vomiting, blurred vision, disturbance of consciousness and epilepsy, with or without signs of nervous system localization. Head CT or cranial MRI and other mostly bilateral multiple cerebral infarction, MRV showed superficial cerebral ventricle, superior sagittal sinus, inferior sagittal sinus, transverse sinus thrombosis. After a comprehensive treatment in addition to 1 case due to hypertension, severe diabetes, causing occipital lobe cerebral hemorrhage, residual cases of residual paralysis were completely recovered. Conclusion Domestic argatroban injection has a positive effect on the venous thrombosis of pregnant women and no obvious side effects on the human body, which is a safe and effective drug for the treatment of venous thrombosis in pregnant women.